Mapk3 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comMapk3 Polyclonal Antibody for Mouse(Mus musculus)

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Mapk3 (Gene name),

Mitogen-activated protein kinase 3 (Protein name ), MK03_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mapk3(Erk1;Prkm3);

Protein name:

Mitogen-activated protein kinase 3(MAP kinase 3;MAPK 3);

Alternative:

Extracellular signal-regulated kinase 1(ERK-1);ERT2;MAP kinase isoform p44(p44-MAPK);Insulin-stimulated MAP2 kinase;Microtubule-associated protein 2 kinase;MNK1;p44-ERK1;Mitogen-activated protein kinase 1(MAP kinase 1;MAPK 1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with HSF4 and NISCH (By similarity). Interacts with MORG1. Interacts with ARRB2 (By similarity). Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14 (By similarity). Interacts with ADAM15.

Function:

Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2) and heat shock factor protein 4 (HSF4) (By similarity). Phosphorylates SPZ1.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

380

Sequence:

50:

100:

150:

200:

250:

300:

350:

380:

MELDDLPKER | LKELIFQETA | RFQPGAPEGP |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q63844

KEGG:

mmu:26417

Pfam:

PF00069

UniGene:

Mm.8385

SMR:

Q63844

Uniprot:

Q63844

FOR

ELISA Kit for Mouse MAP kinase 3

Cat.:

E1357h

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96T

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ELISA Kit for Mouse MAP kinase 3

Cat.:

E1357r

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96T

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ELISA Kit for Mouse MAP kinase 3

Cat.:

E1357m

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96T

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CLIA Kit for Mouse MAP kinase 3

Cat.:

U1357r

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Looking for manual.

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Packing:

96T

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CLIA Kit for Mouse MAP kinase 3

Cat.:

U1357h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse MAP kinase 3

Cat.:

U1357m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse MAP kinase 3

Cat.:

P1357Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MAP kinase 3

Cat.:

P1357Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MAP kinase 3

Cat.:

P1357Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse MAP kinase 3

Protein for Mouse MAP kinase 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Kidney.
tissue: Mammary tumor.
2.

Bienvenut W.V. , Serrels B. , Brunton V.G. , Frame M.C.
Submitted (2008-02) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-65; 89-105; 110-132; 157-209; 213-221; 280-288; 304-319 AND 361-371;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Embryonic fibroblast.
3.

"Molecular cloning of a mouse extracellular signal regulated kinase (erk-1)."
Tanner B. , Mueckler M.
Biochim. Biophys. Acta1171:319-320(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-380
4.

"Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine."
Crews C.M. , Alessandrini A.A. , Erikson R.L.
Proc. Natl. Acad. Sci. U.S.A.88:8845-8849(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-19
tissue: Pre-B cell.
5.

"Molecular analysis of microtubule-associated protein-2 kinase cDNA from mouse and rat brain."
de Miguel C. , Kligman D. , Patel J. , Detera-Wadleigh S.D.
DNA Cell Biol.10:505-514(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 77-380
tissue: Fetal brain.
6.

Lubec G. , Klug S.
Submitted (2007-03) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 136-153 AND 191-209;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Hippocampus.
7.

"Novel CDC2-related protein kinases produced in murine hematopoietic stem cells."
Ershler M.A. , Nagorskaya T.V. , Visser J.W.M. , Belyavsky A.V.
Gene124:305-306(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 171-209
strain: CBA.
tissue: Bone marrow.
8.

"Identification of new protein kinase genes, similar to kinases of the cdc2 family and expressed in murine hematopoietic stem cells."
Ershler M.A. , Nagorskaya T.V. , Visser J.W.M. , Belyavsky A.V.
Dokl. Akad. Nauk SSSR324:893-897(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 171-205
9.

"Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells."
Zhang S. , Mantel C. , Broxmeyer H.E.
J. Leukoc. Biol.65:372-380(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION IN RESPONSE TO FLT3 SIGNALING
10.

"Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways."
Mizuki M. , Fenski R. , Halfter H. , Matsumura I. , Schmidt R. , Muller C. , Gruning W. , Kratz-Albers K. , Serve S. , Steur C. , Buchner T. , Kienast J. , Kanakura Y. , Berdel W.E. , Serve H.
Blood96:3907-3914(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION IN RESPONSE TO FLT3 SIGNALING
11.

"PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase."
Formstecher E. , Ramos J.W. , Fauquet M. , Calderwood D.A. , Hsieh J.C. , Canton B. , Nguyen X.T. , Barnier J.V. , Camonis J. , Ginsberg M.H. , Chneiweiss H.
Dev. Cell1:239-250(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PEA15;SUBCELLULAR LOCATION;FUNCTION OF THE MAPK ERK CASCADE
12.

"Molecular interpretation of ERK signal duration by immediate early gene products."
Murphy L.O. , Smith S. , Chen R.H. , Fingar D.C. , Blenis J.
Nat. Cell Biol.4:556-564(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF FOS;SUBCELLULAR LOCATION
13.

"Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists."
Vomastek T. , Schaeffer H.-J. , Tarcsafalvi A. , Smolkin M.E. , Bissonette E.A. , Weber M.J.
Proc. Natl. Acad. Sci. U.S.A.101:6981-6986(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MORG1
14.

"bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis."
Hsu S.-H. , Hsieh-Li H.-M. , Huang H.-Y. , Huang P.-H. , Li H.
Cancer Res.65:4041-4050(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION OF SPZ1
15.

"Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties."
Parra J.L. , Buxade M. , Proud C.G.
J. Biol. Chem.280:37623-37633(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MKNK2
16.

"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-203 AND TYR-205;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Mast cell.
17.

"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-203 AND TYR-205;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
18.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-203 AND TYR-205;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
20.

"Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling."
Arora D. , Stopp S. , Bohmer S.A. , Schons J. , Godfrey R. , Masson K. , Razumovskaya E. , Ronnstrand L. , Tanzer S. , Bauer R. , Bohmer F.D. , Muller J.P.
J. Biol. Chem.286:10918-10929(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION IN RESPONSE TO FLT3 SIGNALING
21.

"The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions."
Yoon S. , Seger R.
Growth Factors24:21-44(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
22.

"The ERK signaling cascade--views from different subcellular compartments."
Yao Z. , Seger R.
BioFactors35:407-416(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION;REVIEW ON SUBCELLULAR LOCATION
23.

"The ERK cascade: distinct functions within various subcellular organelles."
Wortzel I. , Seger R.
Genes Cancer2:195-209(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION;REVIEW ON FUNCTION

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